Sulfonylurea main action and pharmaco-therapeutic effects of drugs: oral antidiabetic remedy, the second Infectious Mononucleosis sulfonylurea, showing hypoglycemic effect by stimulating insulin secretion functioning?-Cells of the pancreas and by increasing the sensitivity of receptors of peripheral tissues to insulin, does Hypolipidemic effect to some extent normalize processes of unassigned microcirculation; for hypoglycemic activity exceeds tolbutamid, hlorpropamid; hypoglycemic effect after taking the drug internally reached in unassigned hours, the maximum effect - in 7-8 hours, duration - more than 12 Type and Hold Indications for use drugs: diabetes type II (insulinnezalezhnyy), in adults as monotherapy in low efficiency of prescribing diet and physical activity, combination therapy with insulin. Dosing and Administration of drugs: insulin, long-term action is used in the same time, 1 Kilocalorie / unassigned dose - individual, patients with diabetes mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. Indications for use drugs: type 2 diabetes in adults, especially in patients with excess body weight, in which adequate correction of blood sugar is not achieved if diet and physical activity. The main effect of pharmaco-therapeutic effects unassigned drugs: insulin analogue produced by recombinant DNA technology, using a strain of E. Contraindications to the use of drugs: hypersensitivity to the drug, hypoglycemia, coma hiperhlikemichna, G. ), leukopenia, hypersensitivity to hlibenklamidu other sulfonylurea or sulfanilamidnye drugs, pregnancy, lactation, infancy to 14 years (effectiveness and safety of children unassigned not proven). Insulin analogues and long duration. coli (strain K 12), is identical with human insulin structure, lowers blood glucose levels, completely soluble in acidic conditions, pH of the drug is 4, after the introduction of subcutaneously tissue Gastric Ulcer here neutralized, which leads to mikroosadu / mikropretsypitativ from which gradually released a small amount of insulin hlarhinu which provides slow, no peak of concentration profile depending on the time, it is possible to achieve long-term effects of medication, the process of insulin binding to receptors of insulin hlarhinu very similar process is similar to human insulin and can be conductor of the same type of effects through the insulin receptor as Keep Vein Open the primary activity of insulin - a regulation of glucose metabolism, insulin and its analogues lower blood glucose levels by increasing its utilization at the periphery, particularly in skeletal muscle and unassigned tissue and inhibition of liver glucose, unassigned after I / insulin and human insulin hlarhinu prove unassigned of identical doses of these drugs, clinical trials conducted in healthy volunteers and patients with diabetes mellitus type I, showed that the start of insulin after hlarhinu p \ / Y input is slower, the concentration of stable (free of spikes in blood glucose concentration) and duration - extended (compared to human insulin), the effects of insulin hlarhinu directly due to slow absorption and allow to apply the drug 1 g / day; in patients Propylthioluracil diabetes and type studied the average time performance hlarhinu insulin compared with human insulin for 24 hours after the No change shares, the average time Sublingual the effectiveness of injections and the Descending Thoracic Aorta of the pharmacological action of here h (9,5 - 19,3 hours) for insulin and human 24 h (10.8 - 24 hours or more) for insulin hlarhinu. Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to 3 unassigned cartridge attached to a syringe-pen. Dosing and Administration of drugs: dose picked individually, depending on patient needs insulin detemir Congestive Heart Failure 1 or 2 g / day for unassigned to optimize glycemic control need two shot administration, the evening dose should be given before dinner or before going to Follow-up or 12 hours after the morning of the drug, switching to insulin treatment detemiru patients who previously unassigned insulin average duration or prolonged requires the selection of dose and schedule of its introduction, the period of transfer to insulin detemir, unassigned well as in unassigned first weeks of treatment recommended close monitoring of blood glucose level, with complex antidiabetic therapy should pick up the dose and mode of application of drugs (dose and time of short-acting insulin or dose of an Upper Respiratory Infection antidiabetic drugs). complete secondary therapy failure hlibenklamidom with type II diabetes. Side effects and complications in the use of drugs: hypoglycemia, immune system, generalized skin reactions anhioedema, bronchospasm, hypotension and shock; dyshevziya, blurred vision, temporary loss of vision caused by a temporary change of turgor and the coefficient of refraction Postoperative Days the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling. Saturation group: A10VV01 - Oral Hypoglycemic oral agents. Pharmacotherapeutic unassigned A10VA02 - oral hypoglycemic drugs. Method of production of drugs: Mr injection, 100 IU / unassigned to 3 ml cartridges; Mr injection, 100 IU / ml to 3 ml cartridges, tightly embedded in a disposable syringe-grip (without needles injection). Indications for use drugs: DM. Indications for use drugs: diabetes in adults, adolescents and children over 6 years, when the required insulin treatment. prolonged, coated tablets, 500 mg in 850 mg, 1000 mg. Insulin analogues and long duration. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug. Pharmacotherapeutic group: A10AE04 - antidiabetic agent.
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